diff --git a/packages/babel-core/package.json b/packages/babel-core/package.json
index 2a4398509a..de836836e9 100644
--- a/packages/babel-core/package.json
+++ b/packages/babel-core/package.json
@@ -54,6 +54,7 @@
     "@babel/types": "workspace:^7.12.10",
     "convert-source-map": "^1.7.0",
     "debug": "^4.1.0",
+    "escape-string-regexp": "condition:BABEL_8_BREAKING ? ^4.0.0 : ",
     "gensync": "^1.0.0-beta.1",
     "json5": "^2.1.2",
     "lodash": "^4.17.19",
diff --git a/packages/babel-core/src/config/pattern-to-regex.js b/packages/babel-core/src/config/pattern-to-regex.js
index d796617f89..847d0e3226 100644
--- a/packages/babel-core/src/config/pattern-to-regex.js
+++ b/packages/babel-core/src/config/pattern-to-regex.js
@@ -1,6 +1,9 @@
 // @flow
 import path from "path";
-import escapeRegExp from "lodash/escapeRegExp";
+
+const escapeRegExp = process.env.BABEL_8_BREAKING
+  ? require("escape-string-regexp")
+  : require("lodash/escapeRegExp");
 
 const sep = `\\${path.sep}`;
 const endSep = `(?:${sep}|$)`;
@@ -39,11 +42,13 @@ export default function pathToPattern(
         // *.ext matches a wildcard with an extension.
         if (part.indexOf("*.") === 0) {
           return (
+            // $FlowIgnore
             substitution + escapeRegExp(part.slice(1)) + (last ? endSep : sep)
           );
         }
 
         // Otherwise match the pattern text.
+        // $FlowIgnore
         return escapeRegExp(part) + (last ? endSep : sep);
       }),
     ].join(""),
diff --git a/packages/babel-helper-transform-fixture-test-runner/package.json b/packages/babel-helper-transform-fixture-test-runner/package.json
index 349ce9c678..c764d42aae 100644
--- a/packages/babel-helper-transform-fixture-test-runner/package.json
+++ b/packages/babel-helper-transform-fixture-test-runner/package.json
@@ -19,6 +19,7 @@
     "@babel/core": "workspace:^7.12.10",
     "@babel/helper-fixtures": "workspace:^7.12.12",
     "babel-check-duplicated-nodes": "^1.0.0",
+    "escape-string-regexp": "condition:BABEL_8_BREAKING ? ^4.0.0 : ",
     "jest-diff": "^24.8.0",
     "lodash": "^4.17.19",
     "quick-lru": "5.1.0",
diff --git a/packages/babel-helper-transform-fixture-test-runner/src/index.js b/packages/babel-helper-transform-fixture-test-runner/src/index.js
index 8cd92948d4..1b51163495 100644
--- a/packages/babel-helper-transform-fixture-test-runner/src/index.js
+++ b/packages/babel-helper-transform-fixture-test-runner/src/index.js
@@ -7,7 +7,6 @@ import {
 } from "@babel/helper-fixtures";
 import sourceMap from "source-map";
 import { codeFrameColumns } from "@babel/code-frame";
-import escapeRegExp from "lodash/escapeRegExp";
 import * as helpers from "./helpers";
 import merge from "lodash/merge";
 import assert from "assert";
@@ -16,9 +15,13 @@ import path from "path";
 import vm from "vm";
 import checkDuplicatedNodes from "babel-check-duplicated-nodes";
 import QuickLRU from "quick-lru";
-
 import diff from "jest-diff";
 
+// $FlowIgnore
+const escapeRegExp = process.env.BABEL_8_BREAKING
+  ? require("escape-string-regexp")
+  : require("lodash/escapeRegExp");
+
 const cachedScripts = new QuickLRU({ maxSize: 10 });
 const contextModuleCache = new WeakMap();
 const sharedTestContext = createContext();
diff --git a/packages/babel-register/package.json b/packages/babel-register/package.json
index 8bc0cbe75d..22f1a167e2 100644
--- a/packages/babel-register/package.json
+++ b/packages/babel-register/package.json
@@ -17,6 +17,7 @@
     "./lib/nodeWrapper.js": "./lib/browser.js"
   },
   "dependencies": {
+    "escape-string-regexp": "condition:BABEL_8_BREAKING ? ^4.0.0 : ",
     "find-cache-dir": "condition:BABEL_8_BREAKING ? ^3.3.1 : ^2.0.0",
     "lodash": "^4.17.19",
     "make-dir": "^2.1.0",
diff --git a/packages/babel-register/src/node.js b/packages/babel-register/src/node.js
index a27b0c87fd..a3efd4b9e4 100644
--- a/packages/babel-register/src/node.js
+++ b/packages/babel-register/src/node.js
@@ -1,7 +1,6 @@
 import deepClone from "lodash/cloneDeep";
 import sourceMapSupport from "source-map-support";
 import * as registerCache from "./cache";
-import escapeRegExp from "lodash/escapeRegExp";
 import * as babel from "@babel/core";
 import { OptionManager, DEFAULT_EXTENSIONS } from "@babel/core";
 import { addHook } from "pirates";
@@ -9,6 +8,11 @@ import fs from "fs";
 import path from "path";
 import Module from "module";
 
+// $FlowIgnore
+const escapeRegExp = process.env.BABEL_8_BREAKING
+  ? require("escape-string-regexp")
+  : require("lodash/escapeRegExp");
+
 const maps = {};
 let transformOpts = {};
 let piratesRevert = null;
@@ -145,16 +149,19 @@ export default function register(opts?: Object = {}) {
   if (transformOpts.ignore === undefined && transformOpts.only === undefined) {
     transformOpts.only = [
       // Only compile things inside the current working directory.
+      // $FlowIgnore
       new RegExp("^" + escapeRegExp(cwd), "i"),
     ];
     transformOpts.ignore = [
       // Ignore any node_modules inside the current working directory.
       new RegExp(
         "^" +
+          // $FlowIgnore
           escapeRegExp(cwd) +
           "(?:" +
           path.sep +
           ".*)?" +
+          // $FlowIgnore
           escapeRegExp(path.sep + "node_modules" + path.sep),
         "i",
       ),
diff --git a/yarn.lock b/yarn.lock
index 726a06af06..d2b0c76ee7 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -139,6 +139,7 @@ __metadata:
     "@babel/types": "workspace:^7.12.10"
     convert-source-map: ^1.7.0
     debug: ^4.1.0
+    escape-string-regexp: "condition:BABEL_8_BREAKING ? ^4.0.0 : "
     gensync: ^1.0.0-beta.1
     json5: ^2.1.2
     lodash: ^4.17.19
@@ -759,6 +760,7 @@ __metadata:
     "@babel/core": "workspace:^7.12.10"
     "@babel/helper-fixtures": "workspace:^7.12.12"
     babel-check-duplicated-nodes: ^1.0.0
+    escape-string-regexp: "condition:BABEL_8_BREAKING ? ^4.0.0 : "
     jest-diff: ^24.8.0
     lodash: ^4.17.19
     quick-lru: 5.1.0
@@ -3146,6 +3148,7 @@ __metadata:
     "@babel/core": "workspace:*"
     "@babel/plugin-transform-modules-commonjs": "workspace:*"
     browserify: ^16.5.2
+    escape-string-regexp: "condition:BABEL_8_BREAKING ? ^4.0.0 : "
     find-cache-dir: "condition:BABEL_8_BREAKING ? ^3.3.1 : ^2.0.0"
     lodash: ^4.17.19
     make-dir: ^2.1.0
@@ -6467,6 +6470,22 @@ __metadata:
   languageName: node
   linkType: hard
 
+"escape-string-regexp-BABEL_8_BREAKING-true@npm:escape-string-regexp@^4.0.0":
+  version: 4.0.0
+  resolution: "escape-string-regexp@npm:4.0.0"
+  checksum: c747be8d5ff7873127e3e0cffe7d2206a37208077fa9c30a3c1bb4f26bebd081c8c24d5fba7a99449f9d20670bea3dc5e1b6098b0f074b099bd38766271a272f
+  languageName: node
+  linkType: hard
+
+"escape-string-regexp@condition:BABEL_8_BREAKING ? ^4.0.0 : ":
+  version: 0.0.0-condition-76f759
+  resolution: "escape-string-regexp@condition:BABEL_8_BREAKING?^4.0.0:#76f759"
+  dependencies:
+    escape-string-regexp-BABEL_8_BREAKING-true: "npm:escape-string-regexp@^4.0.0"
+  checksum: 1c6b06b9d1094aa0c4bcb60d0d8d82237c35a11132cddf9ecf3fe52a356ae1cf5a65a7d2cfc19cfdb7397474dbbfeafeab74944a5f5e35a6e615db7019209a7d
+  languageName: node
+  linkType: hard
+
 "escape-string-regexp@npm:^1.0.2, escape-string-regexp@npm:^1.0.5":
   version: 1.0.5
   resolution: "escape-string-regexp@npm:1.0.5"