diff --git a/packages/babel-helpers/src/helpers-generated.ts b/packages/babel-helpers/src/helpers-generated.ts
index 9b4b3ebd24..65d723dd40 100644
--- a/packages/babel-helpers/src/helpers-generated.ts
+++ b/packages/babel-helpers/src/helpers-generated.ts
@@ -15,7 +15,7 @@ function helper(minVersion, source) {
 export default Object.freeze({
   applyDecs: helper(
     "7.16.6",
-    'function createMetadataMethodsForProperty(metadataMap,kind,property){return{getMetadata(key){if("symbol"!=typeof key)throw new TypeError("Metadata keys must be symbols, received: "+key);var metadataForKey=metadataMap[key];if(void 0!==metadataForKey)if(1===kind){var pub=metadataForKey.public;if(void 0!==pub)return pub[property]}else if(2===kind){var priv=metadataForKey.private;if(void 0!==priv)return priv.get(property)}else if(Object.hasOwnProperty.call(metadataForKey,"constructor"))return metadataForKey.constructor},setMetadata(key,value){if("symbol"!=typeof key)throw new TypeError("Metadata keys must be symbols, received: "+key);var metadataForKey=metadataMap[key];if(void 0===metadataForKey&&(metadataForKey=metadataMap[key]={}),1===kind){var pub=metadataForKey.public;void 0===pub&&(pub=metadataForKey.public=Object.create(null)),pub[property]=value}else if(2===kind){var priv=metadataForKey.priv;void 0===priv&&(priv=metadataForKey.private=new Map),priv.set(property,value)}else metadataForKey.constructor=value}}}function convertMetadataMapToFinal(obj,metadataMap){var parentMetadataMap=obj[Symbol.metadata],metadataKeys=Object.getOwnPropertySymbols(metadataMap);if(0!==metadataKeys.length){for(var i=0;i<metadataKeys.length;i++){var key=metadataKeys[i],metaForKey=metadataMap[key],parentMetaForKey=parentMetadataMap?parentMetadataMap[key]:null,pub=metaForKey.public,parentPub=parentMetaForKey?parentMetaForKey.public:null;pub&&parentPub&&Object.setPrototypeOf(pub,parentPub);var priv=metaForKey.private;if(priv){var privArr=Array.from(priv.values()),parentPriv=parentMetaForKey?parentMetaForKey.private:null;parentPriv&&(privArr=privArr.concat(parentPriv)),metaForKey.private=privArr}parentMetaForKey&&Object.setPrototypeOf(metaForKey,parentMetaForKey)}parentMetadataMap&&Object.setPrototypeOf(metadataMap,parentMetadataMap),obj[Symbol.metadata]=metadataMap}}function createAddInitializerMethod(initializers){return function(initializer){assertValidInitializer(initializer),initializers.push(initializer)}}function memberDecCtx(base,name,desc,metadataMap,initializers,kind,isStatic,isPrivate){var kindStr;switch(kind){case 1:kindStr="accessor";break;case 2:kindStr="method";break;case 3:kindStr="getter";break;case 4:kindStr="setter";break;default:kindStr="field"}var metadataKind,metadataName,ctx={kind:kindStr,name:isPrivate?"#"+name:name,isStatic:isStatic,isPrivate:isPrivate};if(0!==kind&&(ctx.addInitializer=createAddInitializerMethod(initializers)),isPrivate){metadataKind=2,metadataName=Symbol(name);var access={};0===kind?(access.get=desc.get,access.set=desc.set):2===kind?access.get=function(){return desc.value}:(1!==kind&&3!==kind||(access.get=function(){return desc.get.call(this)}),1!==kind&&4!==kind||(access.set=function(v){desc.set.call(this,v)})),ctx.access=access}else metadataKind=1,metadataName=name;return Object.assign(ctx,createMetadataMethodsForProperty(metadataMap,metadataKind,metadataName))}function assertValidInitializer(initializer){if("function"!=typeof initializer)throw new Error("initializers must be functions")}function assertValidReturnValue(kind,value){var type=typeof value;if(1===kind){if("object"!==type||null===value)throw new Error("accessor decorators must return an object with get, set, or initializer properties or void 0")}else if("function"!==type)throw 0===kind?new Error("field decorators must return a initializer function or void 0"):new Error("method decorators must return a function or void 0")}function applyMemberDec(ret,base,decInfo,name,kind,isStatic,isPrivate,metadataMap,initializers){var desc,initializer,value,decs=decInfo[0];isPrivate?desc=0===kind||1===kind?{get:decInfo[3],set:decInfo[4]}:3===kind?{get:decInfo[3]}:4===kind?{set:decInfo[3]}:{value:decInfo[3]}:0!==kind&&(desc=Object.getOwnPropertyDescriptor(base,name)),1===kind?value={get:desc.get,set:desc.set}:2===kind?value=desc.value:3===kind?value=desc.get:4===kind&&(value=desc.set);var newValue,get,set,ctx=memberDecCtx(base,name,desc,metadataMap,initializers,kind,isStatic,isPrivate);if("function"==typeof decs)void 0!==(newValue=decs(value,ctx))&&(assertValidReturnValue(kind,newValue),0===kind?initializer=newValue:1===kind?(initializer=newValue.initializer,get=newValue.get||value.get,set=newValue.set||value.set,value={get:get,set:set}):value=newValue);else for(var i=0;i<decs.length;i++){var newInit;if(void 0!==(newValue=(0,decs[i])(value,ctx)))assertValidReturnValue(kind,newValue),0===kind?newInit=newValue:1===kind?(newInit=newValue.initializer,get=newValue.get||value.get,set=newValue.set||value.set,value={get:get,set:set}):value=newValue,void 0!==newInit&&(void 0===initializer?initializer=newInit:"function"==typeof initializer?initializer=[initializer,newInit]:initializer.push(newInit))}if(0===kind||1===kind){if(void 0===initializer)initializer=function(instance,init){return init};else if("function"!=typeof initializer){var ownInitializers=initializer;initializer=function(instance,init){for(var value=init,i=0;i<ownInitializers.length;i++)value=ownInitializers[i].call(instance,value);return value}}else{var originalInitializer=initializer;initializer=function(instance,init){return originalInitializer.call(instance,init)}}ret.push(initializer)}0!==kind&&(1===kind?(desc.get=value.get,desc.set=value.set):2===kind?desc.value=value:3===kind?desc.get=value:4===kind&&(desc.set=value),isPrivate?1===kind?(ret.push((function(instance,args){return value.get.call(instance,args)})),ret.push((function(instance,args){return value.set.call(instance,args)}))):2===kind?ret.push(value):ret.push((function(instance,args){return value.call(instance,args)})):Object.defineProperty(base,name,desc))}function applyMemberDecs(ret,Class,protoMetadataMap,staticMetadataMap,decInfos){for(var protoInitializers,staticInitializers,existingProtoNonFields=new Map,existingStaticNonFields=new Map,i=0;i<decInfos.length;i++){var decInfo=decInfos[i];if(Array.isArray(decInfo)){var base,metadataMap,initializers,kind=decInfo[1],name=decInfo[2],isPrivate=decInfo.length>3,isStatic=kind>=5;if(isStatic?(base=Class,metadataMap=staticMetadataMap,kind-=5,staticInitializers||(staticInitializers=[]),initializers=staticInitializers):(base=Class.prototype,metadataMap=protoMetadataMap,protoInitializers||(protoInitializers=[]),initializers=protoInitializers),0!==kind&&!isPrivate){var existingNonFields=isStatic?existingStaticNonFields:existingProtoNonFields,existingKind=existingNonFields.get(name)||0;if(!0===existingKind||3===existingKind&&4!==kind||4===existingKind&&3!==kind)throw new Error("Attempted to decorate a public method/accessor that has the same name as a previously decorated public method/accessor. This is not currently supported by the decorators plugin. Property name was: "+name);!existingKind&&kind>2?existingNonFields.set(name,kind):existingNonFields.set(name,!0)}applyMemberDec(ret,base,decInfo,name,kind,isStatic,isPrivate,metadataMap,initializers)}}protoInitializers&&pushInitializers(ret,protoInitializers),staticInitializers&&pushInitializers(ret,staticInitializers)}function pushInitializers(ret,initializers){initializers.length>0?(initializers=initializers.slice(),ret.push((function(instance){for(var i=0;i<initializers.length;i++)initializers[i].call(instance,instance)}))):ret.push((function(){}))}function applyClassDecs(ret,targetClass,metadataMap,classDecs){for(var initializers=[],newClass=targetClass,name=targetClass.name,ctx=Object.assign({kind:"class",name:name,addInitializer:createAddInitializerMethod(initializers)},createMetadataMethodsForProperty(metadataMap,0,name)),i=0;i<classDecs.length;i++)newClass=classDecs[i](newClass,ctx)||newClass;ret.push(newClass),initializers.length>0?ret.push((function(){for(var i=0;i<initializers.length;i++)initializers[i].call(newClass,newClass)})):ret.push((function(){}))}export default function applyDecs(targetClass,memberDecs,classDecs){var ret=[],staticMetadataMap={};if(memberDecs){var protoMetadataMap={};applyMemberDecs(ret,targetClass,protoMetadataMap,staticMetadataMap,memberDecs),convertMetadataMapToFinal(targetClass.prototype,protoMetadataMap)}return classDecs&&applyClassDecs(ret,targetClass,staticMetadataMap,classDecs),convertMetadataMapToFinal(targetClass,staticMetadataMap),ret}',
+    'function createMetadataMethodsForProperty(metadataMap,kind,property){return{getMetadata(key){if("symbol"!=typeof key)throw new TypeError("Metadata keys must be symbols, received: "+key);var metadataForKey=metadataMap[key];if(void 0!==metadataForKey)if(1===kind){var pub=metadataForKey.public;if(void 0!==pub)return pub[property]}else if(2===kind){var priv=metadataForKey.private;if(void 0!==priv)return priv.get(property)}else if(Object.hasOwnProperty.call(metadataForKey,"constructor"))return metadataForKey.constructor},setMetadata(key,value){if("symbol"!=typeof key)throw new TypeError("Metadata keys must be symbols, received: "+key);var metadataForKey=metadataMap[key];if(void 0===metadataForKey&&(metadataForKey=metadataMap[key]={}),1===kind){var pub=metadataForKey.public;void 0===pub&&(pub=metadataForKey.public=Object.create(null)),pub[property]=value}else if(2===kind){var priv=metadataForKey.priv;void 0===priv&&(priv=metadataForKey.private=new Map),priv.set(property,value)}else metadataForKey.constructor=value}}}function convertMetadataMapToFinal(obj,metadataMap){var parentMetadataMap=obj[Symbol.metadata],metadataKeys=Object.getOwnPropertySymbols(metadataMap);if(0!==metadataKeys.length){for(var i=0;i<metadataKeys.length;i++){var key=metadataKeys[i],metaForKey=metadataMap[key],parentMetaForKey=parentMetadataMap?parentMetadataMap[key]:null,pub=metaForKey.public,parentPub=parentMetaForKey?parentMetaForKey.public:null;pub&&parentPub&&Object.setPrototypeOf(pub,parentPub);var priv=metaForKey.private;if(priv){var privArr=Array.from(priv.values()),parentPriv=parentMetaForKey?parentMetaForKey.private:null;parentPriv&&(privArr=privArr.concat(parentPriv)),metaForKey.private=privArr}parentMetaForKey&&Object.setPrototypeOf(metaForKey,parentMetaForKey)}parentMetadataMap&&Object.setPrototypeOf(metadataMap,parentMetadataMap),obj[Symbol.metadata]=metadataMap}}function createAddInitializerMethod(initializers){return function(initializer){assertValidInitializer(initializer),initializers.push(initializer)}}function memberDecCtx(base,name,desc,metadataMap,initializers,kind,isStatic,isPrivate){var kindStr;switch(kind){case 1:kindStr="accessor";break;case 2:kindStr="method";break;case 3:kindStr="getter";break;case 4:kindStr="setter";break;default:kindStr="field"}var metadataKind,metadataName,ctx={kind:kindStr,name:isPrivate?"#"+name:name,isStatic:isStatic,isPrivate:isPrivate};if(0!==kind&&(ctx.addInitializer=createAddInitializerMethod(initializers)),isPrivate){metadataKind=2,metadataName=Symbol(name);var access={};0===kind?(access.get=desc.get,access.set=desc.set):2===kind?access.get=function(){return desc.value}:(1!==kind&&3!==kind||(access.get=function(){return desc.get.call(this)}),1!==kind&&4!==kind||(access.set=function(v){desc.set.call(this,v)})),ctx.access=access}else metadataKind=1,metadataName=name;return Object.assign(ctx,createMetadataMethodsForProperty(metadataMap,metadataKind,metadataName))}function assertValidInitializer(initializer){if("function"!=typeof initializer)throw new Error("initializers must be functions")}function assertValidReturnValue(kind,value){var type=typeof value;if(1===kind){if("object"!==type||null===value)throw new Error("accessor decorators must return an object with get, set, or initializer properties or void 0")}else if("function"!==type)throw 0===kind?new Error("field decorators must return a initializer function or void 0"):new Error("method decorators must return a function or void 0")}function applyMemberDec(ret,base,decInfo,name,kind,isStatic,isPrivate,metadataMap,initializers){var desc,initializer,value,decs=decInfo[0];isPrivate?desc=0===kind||1===kind?{get:decInfo[3],set:decInfo[4]}:3===kind?{get:decInfo[3]}:4===kind?{set:decInfo[3]}:{value:decInfo[3]}:0!==kind&&(desc=Object.getOwnPropertyDescriptor(base,name)),1===kind?value={get:desc.get,set:desc.set}:2===kind?value=desc.value:3===kind?value=desc.get:4===kind&&(value=desc.set);var newValue,get,set,ctx=memberDecCtx(base,name,desc,metadataMap,initializers,kind,isStatic,isPrivate);if("function"==typeof decs)void 0!==(newValue=decs(value,ctx))&&(assertValidReturnValue(kind,newValue),0===kind?initializer=newValue:1===kind?(initializer=newValue.initializer,get=newValue.get||value.get,set=newValue.set||value.set,value={get:get,set:set}):value=newValue);else for(var i=0;i<decs.length;i++){var newInit;if(void 0!==(newValue=(0,decs[i])(value,ctx)))assertValidReturnValue(kind,newValue),0===kind?newInit=newValue:1===kind?(newInit=newValue.initializer,get=newValue.get||value.get,set=newValue.set||value.set,value={get:get,set:set}):value=newValue,void 0!==newInit&&(void 0===initializer?initializer=newInit:"function"==typeof initializer?initializer=[initializer,newInit]:initializer.push(newInit))}if(0===kind||1===kind){if(void 0===initializer)initializer=function(instance,init){return init};else if("function"!=typeof initializer){var ownInitializers=initializer;initializer=function(instance,init){for(var value=init,i=0;i<ownInitializers.length;i++)value=ownInitializers[i].call(instance,value);return value}}else{var originalInitializer=initializer;initializer=function(instance,init){return originalInitializer.call(instance,init)}}ret.push(initializer)}0!==kind&&(1===kind?(desc.get=value.get,desc.set=value.set):2===kind?desc.value=value:3===kind?desc.get=value:4===kind&&(desc.set=value),isPrivate?1===kind?(ret.push((function(instance,args){return value.get.call(instance,args)})),ret.push((function(instance,args){return value.set.call(instance,args)}))):2===kind?ret.push(value):ret.push((function(instance,args){return value.call(instance,args)})):Object.defineProperty(base,name,desc))}function applyMemberDecs(ret,Class,protoMetadataMap,staticMetadataMap,decInfos){for(var protoInitializers,staticInitializers,existingProtoNonFields=new Map,existingStaticNonFields=new Map,i=0;i<decInfos.length;i++){var decInfo=decInfos[i];if(Array.isArray(decInfo)){var base,metadataMap,initializers,kind=decInfo[1],name=decInfo[2],isPrivate=decInfo.length>3,isStatic=kind>=5;if(isStatic?(base=Class,metadataMap=staticMetadataMap,kind-=5,staticInitializers||(staticInitializers=[]),initializers=staticInitializers):(base=Class.prototype,metadataMap=protoMetadataMap,protoInitializers||(protoInitializers=[]),initializers=protoInitializers),0!==kind&&!isPrivate){var existingNonFields=isStatic?existingStaticNonFields:existingProtoNonFields,existingKind=existingNonFields.get(name)||0;if(!0===existingKind||3===existingKind&&4!==kind||4===existingKind&&3!==kind)throw new Error("Attempted to decorate a public method/accessor that has the same name as a previously decorated public method/accessor. This is not currently supported by the decorators plugin. Property name was: "+name);!existingKind&&kind>2?existingNonFields.set(name,kind):existingNonFields.set(name,!0)}applyMemberDec(ret,base,decInfo,name,kind,isStatic,isPrivate,metadataMap,initializers)}}protoInitializers&&pushInitializers(ret,protoInitializers),staticInitializers&&pushInitializers(ret,staticInitializers)}function pushInitializers(ret,initializers){initializers.length>0?(initializers=initializers.slice(),ret.push((function(instance){for(var i=0;i<initializers.length;i++)initializers[i].call(instance,instance);return instance}))):ret.push((function(instance){return instance}))}function applyClassDecs(ret,targetClass,metadataMap,classDecs){for(var initializers=[],newClass=targetClass,name=targetClass.name,ctx=Object.assign({kind:"class",name:name,addInitializer:createAddInitializerMethod(initializers)},createMetadataMethodsForProperty(metadataMap,0,name)),i=0;i<classDecs.length;i++)newClass=classDecs[i](newClass,ctx)||newClass;ret.push(newClass),initializers.length>0?ret.push((function(){for(var i=0;i<initializers.length;i++)initializers[i].call(newClass,newClass)})):ret.push((function(){}))}export default function applyDecs(targetClass,memberDecs,classDecs){var ret=[],staticMetadataMap={};if(memberDecs){var protoMetadataMap={};applyMemberDecs(ret,targetClass,protoMetadataMap,staticMetadataMap,memberDecs),convertMetadataMapToFinal(targetClass.prototype,protoMetadataMap)}return classDecs&&applyClassDecs(ret,targetClass,staticMetadataMap,classDecs),convertMetadataMapToFinal(targetClass,staticMetadataMap),ret}',
   ),
   asyncIterator: helper(
     "7.15.9",
diff --git a/packages/babel-helpers/src/helpers/applyDecs.js b/packages/babel-helpers/src/helpers/applyDecs.js
index 0cf5489fa1..4c1b91b1b3 100644
--- a/packages/babel-helpers/src/helpers/applyDecs.js
+++ b/packages/babel-helpers/src/helpers/applyDecs.js
@@ -518,9 +518,12 @@ function pushInitializers(ret, initializers) {
       for (var i = 0; i < initializers.length; i++) {
         initializers[i].call(instance, instance);
       }
+      return instance;
     });
   } else {
-    ret.push(function () {});
+    ret.push(function (instance) {
+      return instance;
+    });
   }
 }
 
diff --git a/packages/babel-plugin-proposal-decorators/src/transformer-2021-12.ts b/packages/babel-plugin-proposal-decorators/src/transformer-2021-12.ts
index b963d8fe4f..1e8cc7a188 100644
--- a/packages/babel-plugin-proposal-decorators/src/transformer-2021-12.ts
+++ b/packages/babel-plugin-proposal-decorators/src/transformer-2021-12.ts
@@ -796,11 +796,7 @@ function transformClass(
               if (!path.get("callee").isSuper()) return;
 
               path.replaceWith(
-                t.sequenceExpression([
-                  path.node,
-                  t.cloneNode(protoInitCall),
-                  t.thisExpression(),
-                ]),
+                t.callExpression(t.cloneNode(protoInitLocal), [path.node]),
               );
 
               path.skip();
diff --git a/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor-multiple-super/output.js b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor-multiple-super/output.js
index f29863a7dd..8a52cbd4b2 100644
--- a/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor-multiple-super/output.js
+++ b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor-multiple-super/output.js
@@ -7,9 +7,9 @@ class A extends B {
 
   constructor() {
     if (Math.random() > 0.5) {
-      super(true), _initProto(this), this;
+      _initProto(super(true));
     } else {
-      super(false), _initProto(this), this;
+      _initProto(super(false));
     }
   }
 
@@ -24,7 +24,7 @@ class C extends B {
 
   constructor() {
     try {
-      super((super(), _initProto2(this), this), null.x), _initProto2(this), this;
+      _initProto2(super(_initProto2(super()), null.x));
     } catch {}
   }
 
diff --git a/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/exec.js b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/exec.js
new file mode 100644
index 0000000000..3d81b8cdf4
--- /dev/null
+++ b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/exec.js
@@ -0,0 +1,28 @@
+let self, a, initCalled;
+
+function deco(_, context) {
+  context.addInitializer(() => {
+    initCalled = true;
+  })
+}
+
+class B {
+  constructor(s) {
+    a = s;
+  }
+}
+
+class A extends B {
+  constructor() {
+    let a = 2;
+    self = super(a);
+  }
+
+  @deco
+  method() {}
+}
+
+let instance = new A();
+expect(self).toBe(instance);
+expect(a).toBe(2);
+expect(initCalled).toBe(true);
diff --git a/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/output.js b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/output.js
index 8cbf561af4..e2fb9d7eb3 100644
--- a/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/output.js
+++ b/packages/babel-plugin-proposal-decorators/test/fixtures/2021-12-misc/initProto-existing-derived-constructor/output.js
@@ -7,7 +7,9 @@ class A extends B {
 
   constructor() {
     let a = 2;
-    super(a), _initProto(this), this;
+
+    _initProto(super(a));
+
     foo();
   }